Flight Engineer Mikhall Tyurin will hit three gold plated golf balls from 220 miles above the Earth using a purpose built lightweight six-iron.
He will have to swing the club with one hand as the spacesuit is too cumbersome for a two-handed grip.
The balls will sit in a wire nest to stop them drifting away and are expecting to orbit the Earth for three days.
The cosmonaut has undergone training from Rick Martino and Carol Mann, two of the sport's leading instructors. He will hit the balls away from the station as he and Mike Lopez-Alegria begin a space walk.
The shot will not be the first extraterrestrial game of golf. In 1971 Alan Shepard, the Apollo 14 astronaut ended a Moon walk by driving two balls for hundreds of yards across the lunar surface.
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